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  • JOURNAL ARTICLE
    Tate E, Kallemeijn W, Lueg G, Faronato M, Hadavizadeh K, Goya Grocin A, Song O-R, Howell M, Dinnis Cet al.,

    Validation and invalidation of chemical probes for the human N-myristoyltransferases

    , Cell Chemical Biology, ISSN: 2451-9456
  • JOURNAL ARTICLE
    Tate E, Storck Saha E, Morales Sanfrutos J, Serwa R, Panyain N, Lanyon-Hogg T, Tolmachova T, Ventimiglia L, Martin-Serrano J, Seabra M, Wojciak-Stothard Bet al.,

    Dual Chemical Probes Enable Quantitative System-Wide Analysis of Protein Prenylation and Prenylation Dynamics

    , Nature Chemistry, ISSN: 1755-4330
  • JOURNAL ARTICLE
    Kaiser N, Mejuch T, Fedoryshchak R, Janning P, Tate EW, Waldmann Het al., 2019,

    Photoactivatable Myristic Acid Probes for UNC119-Cargo Interactions

    , CHEMBIOCHEM, Vol: 20, Pages: 134-139, ISSN: 1439-4227
  • JOURNAL ARTICLE
    Benns HJ, Tate EW, Child MA, 2019,

    Activity-Based Protein Profiling for the Study of Parasite Biology.

    , Curr Top Microbiol Immunol, Vol: 420, Pages: 155-174, ISSN: 0070-217X

    Parasites exist within most ecological niches, often transitioning through biologically and chemically complex host environments over the course of their parasitic life cycles. While the development of technologies for genetic engineering has revolutionised the field of functional genomics, parasites have historically been less amenable to such modification. In light of this, parasitologists have often been at the forefront of adopting new small-molecule technologies, repurposing drugs into biological tools and probes. Over the last decade, activity-based protein profiling (ABPP) has evolved into a powerful and versatile chemical proteomic platform for characterising the function of enzymes. Central to ABPP is the use of activity-based probes (ABPs), which covalently modify the active sites of enzyme classes ranging from serine hydrolases to glycosidases. The application of ABPP to cellular systems has contributed vastly to our knowledge on the fundamental biology of a diverse range of organisms and has facilitated the identification of potential drug targets in many pathogens. In this chapter, we provide a comprehensive review on the different forms of ABPP that have been successfully applied to parasite systems, and highlight key biological insights that have been enabled through their application.

  • JOURNAL ARTICLE
    Wang Z, Grosskurth SE, Cheung T, Petteruti P, Zhang J, Wang X, Wang W, Gharahdaghi F, Wu J, Su N, Howard RT, Mayo M, Widzowski D, Scott DA, Johannes JW, Lamb ML, Lawson D, Dry JR, Lyne PD, Tate EW, Zinda M, Mikule K, Fawell SE, Reimer C, Chen Het al., 2018,

    Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer

    , CANCER RESEARCH, Vol: 78, Pages: 6691-6702, ISSN: 0008-5472
  • JOURNAL ARTICLE
    De Vita E, Schuler P, Lovell S, Lohbeck J, Kullmann S, Rabinovich E, Sananes A, Hessling B, Hamon V, Papo N, Hess J, Tate EW, Gunkel N, Miller AKet al., 2018,

    Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity

    , JOURNAL OF MEDICINAL CHEMISTRY, Vol: 61, Pages: 8859-8874, ISSN: 0022-2623
  • JOURNAL ARTICLE
    Beard R, Singh N, Grundschober C, Gee AD, Tate EWet al., 2018,

    High-yielding F-18 radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake in vivo

    , CHEMICAL COMMUNICATIONS, Vol: 54, Pages: 8120-8123, ISSN: 1359-7345
  • JOURNAL ARTICLE
    Beard R, Stucki A, Schmitt M, Py G, Grundschober C, Gee AD, Tate EWet al., 2018,

    Building bridges for highly selective, potent and stable oxytocin and vasopressin analogs

    , BIOORGANIC & MEDICINAL CHEMISTRY, Vol: 26, Pages: 3039-3045, ISSN: 0968-0896
  • CONFERENCE PAPER
    Riviere F, Dian C, Perez-Dorado I, Ritzefeld M, Shen J, Cota E, Meinnel T, Tate EW, Giglione Cet al., 2018,

    Mechanistic insight into HsNMT1-mediated acylation

    , Publisher: WILEY, Pages: 421-422, ISSN: 2211-5463
  • CONFERENCE PAPER
    Tate EW, 2018,

    Protein N terminal modifications: from chemical biology to drug discovery

    , Publisher: WILEY, Pages: 72-73, ISSN: 2211-5463

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